Question

It doesn't make any____now what he says -- it's too late for apologies.

A．difference

B．effect

C．progress

D．development

Answer 1

A

句意:现在你说什么都不起作用了---道歉已为时已晚。make a difference(to) sb/sth有影响,起重要作用；have an effect on sb/sth有影响;有作用;取得进步;make developments取得发展。只有A项从意思和搭配上符合题意。