-What’s wrong with you???? -________.

A. I’m happy.?????????????? B. I have a sore throat.?

C. I have something to do.???? D. Sorry, I don’t know.

 - What's wrong with you, Madam?

    - I've lost my valuable painting. But a week had gone by _______ I knew it was missing.

A. while                            B. since                    C. until                     D. before

 ----What’s up ?

----I failed in the examination of Physics.　

A. How are you?               B. What’s matter with you?

C. What are you doing?          D. What’s wrong with you?

 What's wrong with your car?

    - Well, as you know, cars usually_______ start in winter.

A. don't                   B. shan't                  C. can't                   D. won't