44._______ to give up smoking, he threw away the ______ cigarette.

A. determined, remained　 B. determined, remaining　

C. determining, remaining 　D. determining, remained

43.Laszlo Biro is considered ______ the ball-point pen.

A. to invent　 B. inventing　 C. to be invented　 D. to have invented

42.　 When ______ according to the instructions, the drug has no effect.

A. taking　 B. taken　 C. to take　 D. take

41. If _____ the drug according to the instructions, you will be better soon.

　 A. taking　 B. taken　 C. to take　 D. take

40. With drink and food ____, the prisoner had to walk out of the cave where he was hiding.

A. run out　 B. run out of　 C. use up D. using up

39. The bell _____ the end of the period rang, _____ our heated discussion.

A. indicating, interrupting　 B. indicated, interrupting　

C. indicating, interrupted　 D. indicated, interrupted

38. It is such a problem _____ we all should _______.

A. as, pay attention to it　 B. that, attract our attention

C. as, pay attention to　　 D. as, attract our attention to it.

37. Only after _______ reached eighteen _____ join the army.

A. have you, you can　 　　　　B. have you, can you　

C. you have , you can　 　　　　D. you have, can you

36. The part that women have been ______ in human history is of great importance.

A. taking　 B. doing　 C. playing　 D. making

35. Now you have come to the point ______ a change is needed, or you will fail.

A. when　 B. where　 C. which　 D. that